姓 名: 康九红
性 别: 男
出生年月:1969.9
所属部门:天游线路检测中心
行政职务:院党委书记
学 位:博士
导师情况:博士生导师
研究领域:干细胞与表观遗传学
研究方向:
1)干细胞全能性形成、基因组稳定性及向神经和心肌定向分化的表观遗传机制(非编码RNA、组蛋白修饰和DNA甲基化等)
2)肿瘤形成的信号转导、免疫和表观遗传机制
E-mail:jhkang@tongji.edu.cn
联系电话: 021-65982632
通讯地址:上海市四平路1239号,天游线路检测中心(200092)
情况介绍:
课题组长简介 :
Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, Lu C, Jia W, Xi J, Zhu S, Jiapaer Z, Wan X, Liu Z, Gao S, Kang J#. A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis. Cell Stem Cell. 2018; 22(6):893-908.e6.
Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, Liu Z, Jiapaer Z, Wan X, Wang G, Chen W, Zhu S, Jiang C, Shi W#, Kang J#. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018 May 4. doi: 10.1093/nar/gky347.
Liu Q, Wang G, Lyu Y, Bai M, Jiapaer Z, Jia W, Han T, Weng R, Yang Y, Yu Y, Kang J#. The miR-590/Acvr2a/Terf1 axis regulates telomere elongation and pluripotency of mouse iPSCs. Stem Cell Rep. 2018 Jun 6; pii: S2213-6711(18)30225-X.
Liu Z, Tang M, Zhao J, Chai R#, Kang J#. Looking into the Future: Toward Advanced 3D Biomaterials for Stem-Cell-Based Regenerative Medicine. Adv Mater. 2018; 30(17):e1705388.
Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, Leng Y, Wan X, Kang J#. N6-Methyladenosine modification of lincRNA 1281 iscritically required for mESC differentiation potential. Nucleic Acids Res. 2018;46(8):3906-3920.
Xi J, Wu Y, Li G, Ma L, Feng K, Guo X, Jia W, Wang G, Yang G, Li P#, Kang J#. Mir-29b Mediates the Neural Tube versus Neural Crest Fate Decision during Embryonic Stem Cell Neural Differentiation. Stem Cell Rep. 2017;9(2):571-86
Li G, Jiapaer Z, Weng R, Hui Y, Jia W, Xi J, Wang G, Zhu S, Zhang X, Feng D, Liu L, Zhang X#, Kang J#. Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects. Stem Cell Rep. 2017;8(5):1270-86
Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, Zhu S, Mao Z, Kang J#. Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice. Cell Rep. 2017; 18(12):2880-92
Wei T, Chen W, Wang X, Zhang M, Chen J, Zhu S, Chen L, Yang D, Wang G, Jia W, Yu Y, Duan T, Wu M, Liu H, Gao S, Kang J#. An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells. Nucleic Acids Res. 2015;43(11):5409-22
Liu Q, Wang G, Chen Y, Li G, Yang D, Kang J#. A miR-590/Acvr2a/ Rad51b Axis Regulates DNA Damage Repair during mESC Proliferation. Stem Cell Rep. 2014;3:1103-1117
Wang G, Guo X, Hong W, Liu Q, Wei T, Lu C, Gao L, Ye D, Zhou Y, Chen J, Wang J, Wu M, Liu H, Kang J#. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. PNAS 2013; 110(8):2858-63
Guo X, Liu Q, Wang G, Zhu S, Gao L, Hong W, Chen Y, Wu M, Liu H, Jiang C, Kang J#. microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Res. 2013; 23: 142-56
Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Zhang X, Wang F, Yang R, Fan F, Pei G, Ma L. A nuclear function of beta-arrestin 1 in GPCR Signaling: regulation of histone acetylation and gene transcription. Cell 2005; 123: 833-47
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地址:上海市四平路1239号 电话:021-65981041 传真:65981041